Individual dosimetry system for targeted alpha therapy based on PHITS coupled with microdosimetric kinetic model
نویسندگان
چکیده
Abstract Background An individual dosimetry system is essential for the evaluation of precise doses in nuclear medicine. The purpose this study was to develop a calculating not only absorbed but also EQDX( α / β ) from PET-CT images patients targeted alpha therapy (TAT), considering dose dependence relative biological effectiveness, dose-rate effect, and heterogeneity. Methods A general-purpose Monte Carlo particle transport code PHITS employed as calculation engine system, while microdosimetric kinetic model used converting ). input files describing geometry source distribution patient are automatically created images, using newly developed modules radiotherapy package based on (RT-PHITS). We examined performance by several organ four healthy volunteers after injecting 18 F-NKO-035. Results deposition energy map obtained our seems be blurred image corresponding PET data because annihilation γ-rays deposit their energies rather far location. calculated agree with OLINDA 2.0 within 20%, indicating reliability system. Test calculations replacing labeled radionuclide F 211 At suggest that large heterogeneity target volume expected TAT, resulting significant decrease higher-activity injection. Conclusions As an extension RT-PHITS, medicine coupled model. It enables us predict therapeutic side effects TAT clinical largely available conventional external radiotherapy.
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ژورنال
عنوان ژورنال: EJNMMI Physics
سال: 2021
ISSN: ['2197-7364']
DOI: https://doi.org/10.1186/s40658-020-00350-7