Individual dosimetry system for targeted alpha therapy based on PHITS coupled with microdosimetric kinetic model

نویسندگان

چکیده

Abstract Background An individual dosimetry system is essential for the evaluation of precise doses in nuclear medicine. The purpose this study was to develop a calculating not only absorbed but also EQDX( α / β ) from PET-CT images patients targeted alpha therapy (TAT), considering dose dependence relative biological effectiveness, dose-rate effect, and heterogeneity. Methods A general-purpose Monte Carlo particle transport code PHITS employed as calculation engine system, while microdosimetric kinetic model used converting ). input files describing geometry source distribution patient are automatically created images, using newly developed modules radiotherapy package based on (RT-PHITS). We examined performance by several organ four healthy volunteers after injecting 18 F-NKO-035. Results deposition energy map obtained our seems be blurred image corresponding PET data because annihilation γ-rays deposit their energies rather far location. calculated agree with OLINDA 2.0 within 20%, indicating reliability system. Test calculations replacing labeled radionuclide F 211 At suggest that large heterogeneity target volume expected TAT, resulting significant decrease higher-activity injection. Conclusions As an extension RT-PHITS, medicine coupled model. It enables us predict therapeutic side effects TAT clinical largely available conventional external radiotherapy.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Estimation of relative biological effectiveness for boron neutron capture therapy using the PHITS code coupled with a microdosimetric kinetic model

The absorbed doses deposited by boron neutron capture therapy (BNCT) can be categorized into four components: α and (7)Li particles from the (10)B(n, α)(7)Li reaction, 0.54-MeV protons from the (14)N(n, p)(14)C reaction, the recoiled protons from the (1)H(n, n) (1)H reaction, and photons from the neutron beam and (1)H(n, γ)(2)H reaction. For evaluating the irradiation effect in tumors and the s...

متن کامل

Biological dose estimation for charged-particle therapy using an improved PHITS code coupled with a microdosimetric kinetic model.

Microdosimetric quantities such as lineal energy, y, are better indexes for expressing the RBE of HZE particles in comparison to LET. However, the use of microdosimetric quantities in computational dosimetry is severely limited because of the difficulty in calculating their probability densities in macroscopic matter. We therefore improved the particle transport simulation code PHITS, providing...

متن کامل

Validation of the physical and RBE-weighted dose estimator based on PHITS coupled with a microdosimetric kinetic model for proton therapy

The microdosimetric kinetic model (MKM) is widely used for estimating relative biological effectiveness (RBE)-weighted doses for various radiotherapies because it can determine the surviving fraction of irradiated cells based on only the lineal energy distribution, and it is independent of the radiation type and ion species. However, the applicability of the method to proton therapy has not yet...

متن کامل

mortality forecasting based on lee-carter model

over the past decades a number of approaches have been applied for forecasting mortality. in 1992, a new method for long-run forecast of the level and age pattern of mortality was published by lee and carter. this method was welcomed by many authors so it was extended through a wider class of generalized, parametric and nonlinear model. this model represents one of the most influential recent d...

15 صفحه اول

Systemic Targeted Alpha Radiotherapy for Cancer

Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: EJNMMI Physics

سال: 2021

ISSN: ['2197-7364']

DOI: https://doi.org/10.1186/s40658-020-00350-7